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Pyruvate Dehydrogenase E1 beta subunit Antibody (YA114) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets the Pyruvate Dehydrogenase E1 beta subunit. This antibody is designed for research use only and is a component of the pyruvate dehydrogenase complex, which links the glycolytic pathway to the tricarboxylic acid cycle by catalyzing the conversion of pyruvate to acetyl-CoA and CO₂.
Host: Rabbit
Reactivity: Human, mouse, rat
Conjugation: Non-conjugated
SwissProt ID: P11177
Research field: Signal transduction
Formulation: Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% glycerol. Preservative: 0.05% sodium azide
Appearance: Liquid
Applications include WB (1:500-1:2000), IHC-P (1:50-1:200), FC (1:50-1:100), and IP
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Ethyl pyruvate is a simple derivative of the endogenous metabolite pyruvate Ethyl pyruvate is an HMGB1 release inhibitor Ethyl pyruvate can induce apoptosis by autophagy Ethyl pyruvate has anti-inflammatory antioxidant and anti-tumor activity Ethyl pyruvate can be used in the study of neurodegenerative diseases such as Alzheimer s and Parkinson s disease[1][2][3][4][5]
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Pyruvate Carboxylase-IN-1 is a small-molecule inhibitor of pyruvate carboxylase provided as a research reagent. It has the molecular formula C15H14O3, a molecular weight of 242.27, and a reported purity of 99.4%. Supplied as a solid in multiple small pack sizes, it is intended for laboratory research use only; consult the datasheet and SDS for handling and safety information.
Reported purity of 99.4%.
Designed for studies of pyruvate carboxylase and mitochondrial metabolism.
Available in multiple small pack sizes suitable for bench research.
Provided with a product datasheet and safety data sheet.
Intended for research use only; not for clinical applications.
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Pyruvate Carboxylase-IN-1 is a potent inhibitor of pyruvate carboxylase with antiproliferative activity. It shows inhibitory effects on the growth of HepG2 and HCCLM3 cells.
Potent pyruvate carboxylase inhibitor
Exhibits antiproliferative activity
Inhibits HepG2 cell growth (IC50 1.741 μM)
Inhibits HCCLM3 cell growth (IC50 8.540 μM)
For research use only
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